mild cognitive impairment
Conditions
Interventions
Gold Standard:Clinical outcomes
Index test:The 
occurrence 
and 
evaluation 
of 
in 
patients 
with 
disease
Sponsors
The First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18-80 years; (2) CKD patients: eGFR = 30mg/d or urine albumin-creatinine ratio ACR >= 30mg/g); or both are consistent. Hemodialysis patients: should maintain hemodialysis for more than 3 months; (3) The life expectancy exceeds 6 months; (4) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Poor compliance, unable to follow up on schedule; (2) Are participating in interventional clinical trials; (3) Dementia or other mental and cognitive disorders, limited physical activity, severe visual impairment, etc. cannot cooperate to complete the assessment; (4) The expected survival period is less than 6 months; (5) Severe cardiac insufficiency (NYHA grade III or IV heart failure, that is, basic heart disease, obvious limitation of physical activity, fatigue, palpitations, wheezing or angina can occur under normal physical activity or even at rest); (6) The diagnosis of CKD is and only simple hematuria: that is, centrifugal urine sediment microscopy shows that red blood cells are >= 3/high-powered field of view, and it is glomerular-derived hematuria (mainly abnormal red blood cells). Without hypertension, proteinuria (including microalbuminuria) and eGFR >= 60mL/min/1.73m2. Exclude urinary tract infections, tumors, drugs and other factors that cause false positives; (7) Acute kidney injury (AKI) patients, that is, serum creatinine rises >= 0.3mg/dl within 48 hours; or serum creatinine exceeds 1.5 times the baseline value within 7 days; or urine output < 0.5ml/kg/ h is greater than 6 hours; (8) Acute disease state: such as infection, fever, acute coronary syndrome, etc.; or during the acute attack of chronic disease; (9) HIV infection or AIDS.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RT;Blood chemistry;Serum Cystatin C;Homocysteine;Full parathyroid hormone;High sensitivity C-reactive protein;Glycated hemoglobin;25(OH)VitD3;Alkaline phosphatase;Folic acid;VitB12;Serum Fe;Serum ferritin;Urine routine;24h urine biochemistry;Urine albumin/creatinine ratio;SEN, SPE, ACC, AUC of ROC, PPV, NPV.; | — |
Countries
China
Contacts
Public ContactXiaohua Pei
The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed