heart failure
Conditions
Interventions
ARNI group:ARNI 24/26mg bid
49/51mg bid
97/103mg bid
ARB group:ARB 40mg bid
80mg bid
160mg bid
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
75 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Aged >= 75 years, no limitation of gender; 2) New York Heart Function Association (NYHA) of ADHF inpatients (with symptoms and signs of fluid retention): Grade II-IV heart failure; 3) ADHF >= 24 hours and = 40% (based on echocardiography, MUGA, CT, MRI or ventricular angiography); N-terminal pro-B natriuretic peptide (NT-proBNP) >= 1800 ng/L in the past 6 months or B-type natriuretic peptide (BNP) >= 400 pg/ml; 5) Hemodynamically stable, defined as patients receiving ACEI/ARB treatment within 24 hours before randomization, systolic blood pressure (SBP) >= 100 mmHg at random; patients who did not receive ACEI/ARB treatment within 24 hours before randomization, SBP >= 110mmHg at random; No intravenous diuretics, vasodilators, blood pressure boosters, and / or positive inotropic drugs within the first 24 hours; 6) Informed consent.
Exclusion criteria
Exclusion criteria: 1) Symptomatic hypotension; 2) History of angioedema; 3) Known or suspected bilateral renal artery stenosis; 4) Calculate eGFR 5.3 mmol / L when randomized; 6) Liver injury (if tested, total bilirubin> 3.0 mg / dL or elevated ammonia levels), or evidence of liver cirrhosis with portal hypertension, such as esophageal varices; 7) Have a history of allergies to research drugs or other drugs in similar chemical categories; 8) History of malignant tumors of any organ system (except localized skin basal cell carcinoma) in the past 3 years, and life expectancy is less than 1 year; 9) History or evidence of drug or alcohol abuse in the past 12 months; 10) The patient was deemed unsuitable to participate in the study, including mental, behavioral, or cognitive impairments that were sufficient to affect the patient's ability to understand, obey the protocol, or complete follow-up procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NT-proBNP; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart structure;NYHA classification;KCCQ;Heart failure rehospitalization;Cardiovascular mortality; | — |
Countries
China
Contacts
Public ContactLiang Jing
Shanghai General Hospital
Outcome results
None listed