acute kidney injury
Conditions
Interventions
early initiation group:Accelerated RRT initiatio
late initiation group:Standard RRT initiation
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years. 2. Evidence of kidney dysfunction (serum creatinine >= 115µmol/L). 3. Evidence of severe AKI based on at least two of the following two criteria. a. A 2-fold increase in serum creatinine during hospitalization or from a known prehospitalization baseline. b. Oliguria as defined by urine output = 5% of body weight.
Exclusion criteria
Exclusion criteria: 1. Serum potassium >= 5.5 mmol/L. 2. Serum bicarbonate 80%, PEEP> 10mmHg). 4. Presence of a drug overdose that necessitates initiation of RRT. 5. Lack of commitment to ongoing life support,including RRT. 6. Known pre-hospitalization advanced chronic kidney disease, defined by an estimated glomerular filtration rate < 20 mL/minute/1.73 m2, or chronic RRT. 7. Retrorenal obstruction, rapidly progressive nephritis, vasculitis, multiple myeloma and thrombotic microangiopathy have been confirmed or suspected.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| medical history;sCr;urine output;baseline laboratry test;60-day mortality;ICU days;RRT dependence; | — |
Countries
China
Contacts
Public ContactMeili Duan
Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed