Surgical sedation and ischemia reperfusion
Conditions
Interventions
Experimental group:Different doses of remidazolam were pumped
Experimental group E:Effective dose of remidazolam was pumped
Control group F :Midazolam pump injection
Group B:Pumping normal saline
Group M:Midazolam was pumped
Sponsors
Shaoyang Central Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients with ASA I - II grade; 2. Patients without contraindications of intraspinal anesthesia; 3. Patients aged 40-60 years; 4. Patients with body mass index (BMI) of 18.5-24 kg / m2; 5. Patients with bmr-11% - 11%.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of cardiovascular system, central nervous system and mental illness; 2. Patients with history of sleep apnea hypopnea syndrome and respiratory failure; 3. Patients with a history of endocrine diseases such as hyperthyroidism, hypothyroidism and chronic adrenocortical hypofunction (Addison's disease); 4. Patients with history of dependence or allergy to analgesics and sedatives; 5. Patients with liver and kidney dysfunction; 6. Patients with communication barriers; 7. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bispectral index;modified observer's assessment of alert /sedation;malondialdehyde;Superoxide dismutase;Interleukin-6;Tumor necrosis factor - a;miR-92a;vascular endothelial growth factor; | — |
Secondary
| Measure | Time frame |
|---|---|
| Forgetting test; | — |
Countries
China
Contacts
Public ContactBinghua He
Shaoyang Central Hospital
Outcome results
None listed