osteoarthritis
Conditions
Interventions
Trial group:intra-articular injection 0.5g tranexamic acid
placebo group:intra-articular injection 0.5 g placebo
Sponsors
Department of Orthopedics, West China Hospital, Sichuan University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed as knee osteoarthritis requiring unilateral primary TKA surgery. 2. American Society of Anesthesiologists degree before operation: I~III grade. 3. Over 18 years of age.
Exclusion criteria
Exclusion criteria: 1. People who are allergic to tranexamic acid; 2. There was an operative knee deformity (buckling deformity > 20 degrees; Varus and valgus deformity BBB 0 20 degrees) and stiffness of joints; 3. Revision partial or total knee replacement, suppurative arthritis or post-traumatic arthritis; 4. Serious cardiovascular and respiratory diseases; Kidney and liver failure, history of kidney transplantation; 5. Refusing to participate in or accept blood products.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain score (VAS);Morphine consumption; | — |
Secondary
| Measure | Time frame |
|---|---|
| total blood loss;Invisible blood loss;Intraoperative blood loss;volume of drainage;Inflammatory markers;range of motion;Blood transfusion rate (%);LOS (length of stay); | — |
Countries
China
Contacts
Public ContactKang Pengde
Department of Orthopedics, West China Hospital, Sichuan University
Outcome results
None listed