Dentition defect
Conditions
Interventions
A:Biomimetic Calcium Phosphate (rhBMP-2/BioCaP/ß-TCP)
B:ß-TCP
C:natural healing group
Sponsors
The Ninth People's Hospital Affiliated to medical school of Shanghai Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients over 18 years old; 2. Patients with single tooth extraction in accordance with the indications of tooth extraction; 3. The subjects who met the indications for site preservation (eds-1 and eds-2 grades according to n. caplanis et al. (2005)); 4. Patients choose to receive implant therapy; 5. The subjects voluntarily signed the informed consent form before carrying out any research related trial steps.
Exclusion criteria
Exclusion criteria: 1. Oral implant placement contra-indication according to Hwang et al. 2. Patients with uncontrolled local inflammation of extracted teeth and adjacent teeth, including uncontrolled periodontitis (periodontal probing depth > 4mm) and acute periapical periodontitis; 3. Patients with stable diabetes, fasting blood glucose is still >= 8.8 mmol / L after drug control); 4. Patients with uncontrolled severe hypertension (higher than 180 / 100 mmHg); 5. In obese patients, BMI > 28 kg / m^2; 6. Patients who received antibiotic therapy or chronic anti-inflammatory therapy (more than 3 times a week) in the first 4 weeks before operation; 7. Smoking / tobacco equivalent / chewing tobacco more than 10 cigarettes per day; 8. Patients allergic to products; 9. Pregnant or lactating women or female patients who refuse to take contraceptive measures during clinical trials; 10. Patients with poor compliance who could not participate in the trial according to the researchers; 11. Within 30 days prior to the start of surgery (study day 0), patients participated in clinical trials of other drug devices.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The volume density of the new bone in biopsy samples at the tooth extraction site 6 weeks after preservation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Volume density of residual bone filling material in biopsy samples at tooth extraction site 6 weeks after preservation;The contour width and height of the hard tissue changed 6 weeks after tooth extraction;Surface area change of soft tissue in the sagittal plane at 6 weeks after tooth extraction;Soft tissue healing score at 6 weeks after tooth extraction; | — |
Countries
China
Contacts
Public ContactWu Yiqun
The Ninth People's Hospital Affiliated to medical school of Shanghai Jiaotong University
Outcome results
None listed