Major depressvie disorder
Conditions
Interventions
Precise TMS group :Precise TMS using 3D printed localizer
Conventional TMS control group (1):conventional TMS without precisely targeting (1)
Precise TMS group:Precise TMS using augmented reality (AR)-based navigator
Conventional TMS control group (2):conventional TMS without precisely targeting (2)
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients who meet the diagnostic criteria of major depressive disorder in dsm-5 (by SCID and clinical diagnosis by a chief physician); 2. Patients who agreed to receive rTMS treatment; 3. Patients aged 18-65 years old; 4. Subjects with junior high school education or above; 5. First or recurrent patients; 6. Subjects with HAMD-17 score >= 14; 7. Patients who failed to receive a full dose of SSRI antidepressant or were intolerant of at least one antidepressant; 8. Patients with no change of drug treatment dose 2 weeks before enrollment.
Exclusion criteria
Exclusion criteria: 1. Patients with substance related disorders diagnosed by dsm-5 in recent three months; 2. Patients with schizophrenia and other primary psychotic disorders, obsessive-compulsive disorder, post-traumatic stress disorder, anxiety disorder and personality disorder diagnosed by dsm-5; 3. Patients with serious heart disease or pacemaker implantation; 4. Patients with serious negative ideas and behaviors; 5. Pregnant or lactating women; 6. Patients who had been treated with ECT or TMS were ineffective; 7. Patients with any nervous system diseases, including intracranial injury, epilepsy, Parkinson's disease, etc; 8. Patients with intracranial metal implants or other contraindications for TMS treatment; 9. Patients with anticonvulsant drugs or more than 2mg of diazepam; 10. Patients with claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of HAMD-17 scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes of HAMA-14 scores;Neuroimgaing biomarkers; | — |
Countries
China
Contacts
Public ContactYingying Tang
Shanghai Mental Health Center
Outcome results
None listed