Amblyopia
Conditions
Interventions
Strabismic amblyopia:Nil
Anisometropic amblyopia:Nil
control group:Nil
Sponsors
The First Affiliated Hospital with Nanjing Medical University, Nanjing, China
Eligibility
Sex/Gender
All
Age
5 Years to 10 Years
Inclusion criteria
Inclusion criteria: 1. Aged 5-10 years old, able to cooperate with the relevant ophthalmic examination of monocular amblyopia children; 2. strabismus amblyopia, anisometropia amblyopia, strabismus children without strabismus surgery; 3. The best corrected visual acuity (BCVA) of amblyopia was less than that of normal BCVA of corresponding age group, and the difference of BCVA between two eyes was >=0.2 LogMAR. Strabismus amblyopia group: 1. Patients with strabismus at the time of examination; 2. The difference of binocular hyperopia equivalent spherical lens =1.00d, 2. The difference of equivalent spherical lens in binocular myopia is more than 3.00d; 3. The degree difference of binocular colonoscopy >=1.50D. The standard of healthy control group was as follows: 1. Normal non amblyopia children aged 5-10 years who can cooperate with relevant ophthalmic examination; 2. The best corrected visual acuity of 5-year-old children >=0.5, 6-year-old children >=0.7, and over 7-year-old children >=0.8, and the difference of best corrected visual acuity between the two eyes was <=0.2logmar; 3. Binocular equivalent spherical lens <=0.50D, binocular cylindrical lens power difference <=1.00d; 4. Those who are willing to participate in this study and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. The patient had a history of glaucoma, choroidal hemangioma, ptosis, nystagmus, media opacity and ocular diseases; 2. Children with binocular amblyopia, strabismus and anisometropia; 3. Patients with ocular organic diseases or developmental abnormalities and retinal diseases, such as congenital microphthalmos, DRS syndrome, morning glory syndrome, PHPV, etc; 4. Patients with history of severe ocular trauma and operation; 5. Patients with systemic vascular diseases or diseases that may affect ocular microvascular, such as type 1 diabetes mellitus, Sturge Weber syndrome, etc; 6. Patients with mental disorders or communication disorders, such as autism, cerebral palsy; 7. One of the parents is suffering from hereditary diseases related to retina or blood vessels, both parents are unable to communicate with each other, hearing impairment or complete civil capacity; 8. Patients with other head, brain or eye diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| visual acuity;contrast sensitivity;refraction diopter;axial length;vessel density;retinal thickness;foveal avascular zone;retinal blood flow area; | — |
Countries
China
Contacts
Public ContactLiu Hu
The First Affiliated Hospital with Nanjing Medical University, Nanjing, China
Outcome results
None listed