Diarrhea-Irritable Bowel Syndrome
Conditions
Interventions
Healthy control group:Nil
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: IBS-D group 1. According to Rome IV diarrhea irritable bowel syndrome diagnostic criteria, and in line with the diagnosis of liver depression and spleen deficiency syndrome; 2. The age is between 18 and 70 years old 3. No antibiotics, steroids and other hormones, Chinese herbal medicine preparations (including oral and intravenous injection), probiotics or yoghurt were taken in recent month; 4. They signed informed consent and were willing to receive corresponding treatment. Healthy control group 1. The age ranged from 18 to 70 years old; 2. Those who know and are willing to sign informed consent.
Exclusion criteria
Exclusion criteria: IBS-D group 1. Patients with severe heart, liver, kidney and other major organ diseases, hematopoietic system, nervous system or mental disease; 2. Combined with other organic diseases of the digestive system (such as peptic ulcer), recent colonoscopy revealed organic diseases such as tumors, or systemic diseases affecting gastrointestinal motility (such as hyperthyroidism and diabetes mellitus); 3. Those who are or need to continue to use drugs that may affect gastrointestinal function (antidiarrheal agents, antidepressants, anti anxiety drugs, intestinal flora regulators, antibiotics, etc.); 4. Those who have a history of allergy to related drugs and severe food allergy used in the study; 5. There are any forms of ongoing psychotherapy; 6. A woman who is pregnant or is preparing for pregnancy, a lactating woman. 7. Patients who are participating in clinical trials of other drugs within 4 weeks. Healthy control group 1. Pregnant or preparing for pregnancy, lactating women; 2. Diabetes, hyperthyroidism, chronic renal insufficiency and other diseases, combined with heart, liver, kidney, brain and hematopoietic system and other serious diseases; 3. Severe mental illness, serious mental retardation, unable to cooperate with examination and treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut microbiota;Fecal bile acids;Related indexes of intestinal mucosal barrier function;Visceral hypersensitivity related indicators; | — |
Countries
China
Contacts
Public ContactHuang shaogang
Guangdong Provincial Hospital of Chinese Medicine
Outcome results
None listed