osteoarthritis
Conditions
Interventions
trial group:Oral losartan 50mg/ for 2 years
control group:Oral placebo 50mg/ for 2 years
Sponsors
Shenzhen Second People's Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Aged 50 ~ 75 years; (2) Conform to comply with the American?College of Rheumatology (ACR) knee osteoarthritis diagnostic criteria; (3) Mild-to-moderate OA: Kellgren - Lawrence class 2-3 (one or both knees); (4) Merge with moderate hypertension, systolic blood pressure of 160 ~ 179 MMHG or diastolic blood pressure of 100 ~ 109 MMHG, need oral more than 2 kinds of anti-hypertensive drug treatment; (5) With synovitis of clinical symptoms (fever, swelling), and confirmed by MRI; (6) Pain (VAS) >= 40mm; Knee pain over 3 months; Pain (VAS) of the lateral side < 30 mm.
Exclusion criteria
Exclusion criteria: (1) Allergic to pharmaceutical ingredients; (2) is given priority to with knee pain of patients; (3) Body mass index over 32 kg/M2 ; (4) Received angiotensin II blockers (Ang II RAS) or other biological preparation in 3 months; (5) Received non-steroidal anti-inflammatory drug treatmen in 2 weekst; (6) has a history of knee surgery in 10 years; (7) Accompanied by other complications or joint disease (such as septic arthritis, acute or chronic inflammation of the joints, hemorrhagic stripped bone chondritis, osteonecrosis, blood disease, etc.); (8) Serious joint deformation or joint deformities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WOMAC pain score;VAS pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| WOMAC function score;WOMAC stiffness score;patient global assessment (PGA);30s-CST;40m FPWT;Sf-36 Health Scale; | — |
Countries
China
Contacts
Public ContactZhenhan Deng
Shenzhen Second People's Hospital
Outcome results
None listed