Alzheimer's Disease
Conditions
Interventions
Gold Standard:Clinical symptoms, neuropsychological scale, imaging indicators.
Index test:Fundus 
image, 
photographic 
image 
and 
Sponsors
Ningbo Kangning Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Male or postmenopausal women, aged 60-75 years; 2. Those who meet the criteria of ICD-10 for the clinical diagnosis of Alzheimer's disease; 3. Subjects with MMSE score lower than 25; 4. Have the ability to complete the cognitive ability test and the test objects specified in the program; 5. Hachinski ischemic scale score = 4, excluding vascular factors; 6. Hamilton Depression Scale (HAMD) 24 item version total score = 8, excluding depression factors.
Exclusion criteria
Exclusion criteria: 1. Patients with severe physical diseases, such as severe heart disease, malignant tumor, etc; 2. Patients with severe mental symptoms or mental illness, such as schizophrenia; 3. Patients with alcohol and drug abuse; 4. Patients with severe depression and serious suicide risk; Five Patients with dementia caused by other causes: vascular dementia, central nervous system infection (such as AIDS, syphilis, etc.), Lewy body dementia, traumatic dementia, other physical and chemical factors (such as drug poisoning), intracranial space occupying lesions (such as subdural hematoma, brain tumors), endocrine system lesions (such as thyroid disease, parathyroid disease), vitamins or other Dementia of any cause. 6. History or screening of patients with brain MRI showing the following abnormalities: cerebral hemorrhage, brain trauma, aneurysm, arteriovenous malformation, subdural hematoma, intracranial space occupying, etc; 7. Patients who have undergone ophthalmic surgery recently; 8. Patients with other conditions considered unsuitable for the study; 9. Those who do not sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fudus Aß content; | — |
Secondary
| Measure | Time frame |
|---|---|
| Thickness of retina; | — |
Countries
China
Contacts
Public ContactMei Xi
Ningbo Kangning Hospital
Outcome results
None listed