Relationship between external cooling and prognosis of septic shock and its inflammatory mechanism: a randomized controlled trial.

Relationship between external cooling and prognosis of septic shock and its infl

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000035240

Enrollment

Unknown

Registered

2020-08-04

Start date

2020-08-01

Completion date

Unknown

Last updated

2020-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic shock

Interventions

trial group:The temperature was reduced to the target temperature within 2 hours and maintained for 48 hours.

control group:No temperature intervention was carried out within 48 hours. Only when the patient's temperature is higher than 40 ?, the clinician will decide whether to lower the temperature and the s

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with septic shock; 2. Patients with core body temperature >= 38.3 degrees C; 3. Patients with expected length of stay in ICU greater than or equal to 72 hours.

Exclusion criteria

Exclusion criteria: 1. Patients younger than 18 years old; 2. Patients with body temperature > 40 degrees C; 3. Pregnant and lactating patients; 4. Patients who need antipyretic drugs 6 hours before and after enrollment; 5. Patients with traumatic brain injury; 6. Patients with tumor; 7. Patients with autoimmune diseases; 8. Patients requiring CRRT.

Design outcomes

Primary

Measure	Time frame
28-day mortality rate;	—

Secondary

Measure	Time frame
?72h SOFA score;ICU LOS;	—

Countries

China

Contacts

Public ContactShao Jun

Dalian Medical University

sjun1982@163.com+86 18051061365

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026