Membranous Nephropathy
Conditions
Interventions
Sponsors
Beijing Hospital of TCM
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged between 18 and 75 years old; 2. The patients who met the diagnostic criteria of Western medicine for membranous nephropathy, and met the requirement that the 24-hour urine protein quantity of the enrolled patients was still more than 5g after 12 weeks of follow-up (i.e., they could not spontaneously relieve); 3. Patients who meet the diagnostic criteria of syndrome accumulation of Yang deficiency syndrome in TCM; 4. Patients who have signed informed consent form; 5. Ckd1-3, EGFR (EPI formula) >=40ml / min, serum albumin > 15g / L.
Exclusion criteria
Exclusion criteria: 1. Patients with progressive membranous nephropathy (progressive decline of renal function; necrotizing capillary inflammation and > 50% crescentic formation) in renal biopsy, accompanied with IgA nephropathy, diabetic nephropathy and other kidney diseases; 2. Patients with abnormal antinuclear antibody, double stranded DNA, ANCA or other immune diseases; 3. Patients with active hepatitis B and abnormal transaminase in continuous liver function test; Patients with history of HIV / AIDS, severe gastrointestinal cancer, or history of central nervous system malignancy; 4; 5. Patients with life-threatening complications such as severe infection or severe diseases and dysfunction of other organs; 6. The subjects known to be allergic to the components of the traditional Chinese medicine granules used; 7. Pregnant or lactating women; 8. Subjects undergoing other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anti-PLA2R Antibody;24-hour urine protein;Blood albumin;TCM syndrome scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum creatinine;Blood urea nitrogen;Total Cholesterol;Triglyceride; | — |
Countries
China
Contacts
Public ContactLiu Baoli
Beijing Hospital of traditional Chinese Medicine Affiliated to Capital Medical University
Outcome results
None listed