Benign childhood epilepsy with centro-temporal spikes, BECT
Conditions
Interventions
patients with BECT aged 3-15 years:Nil
healthy children control group:Nil
patients with medial temporal lobe epilepsy (MTLE) aged 18-65 years:Nil
healthy adults control group:Nil
Sponsors
Henan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
3 Years to 65 Years
Inclusion criteria
Inclusion criteria: Experiment 1: (1) Ages 3-15 years, regardless of gender; (2) Patients aged 3-15 years who met the BECTs diagnostic criteria of the International Union against Epilepsy (ILAE) in 1989; (3) Normal nervous system examination; (4) Focal convulsions or paresthesia of the upper and lower limbs of the face or one side; (5) The attack occurs in the sleeping period or awakening period; (6) Electroencephalogram showed that high amplitude spinous wave or slow spinous complex wave appeared in the central temporal region, which may spread to the opposite side, and background activity remained normal; (7) No evidence of progressive brain or systemic disease; (8) Head CT/ magnetic resonance imaging (MRI) results were normal; (9) The patient or family member agrees and signs the consent form; Experiment 2: (1) Ages 18-65, regardless of gender; (2) Simple mental State examination (MMSE) score >= 25; (3) Have at least primary school education, and can cooperate to complete the neuropsychological function test; (4) The enrolled patients all received appropriate antiepileptic drug therapy, with the exception of phenobarbital, clonazepam, phenytoin sodium, topiramate and other drugs that may affect cognition; (5) The disease was well controlled and had no onset in the past 3 months. It should be noted that whether you can participate in the study or not will need to be examined by a doctor before a final decision is made.
Exclusion criteria
Exclusion criteria: Experiment 1: (1) Any medical history or brain structural MRI abnormalities that may exclude BECTs diagnosis; (2) Any accompanying neurological disease; (3) Neuropsychiatric retardation or abnormal neurological examination; Experiment 2: (1) Cognitive impairment related to various non-epileptic factors; (2) Any mental illness, neurological disease and systemic chronic or progressive disease; (3) Use antipsychotics or sedatives that may affect cognition.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 10-hour video eeg; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuropsychological test;Simple mental state examination score;Simple cognitive scale; | — |
Countries
China
Contacts
Public ContactHan Xiong
Henan Provincial People's Hospital
Outcome results
None listed