chronic post-surgical pain
Conditions
Interventions
Parecoxib sodium +PCEA:Intravenous injection of Parecoxib sodium 40mg (diluted with normal saline to 4mL) started immediately before surgery and continued for 3 days after surgery
The placebo + PCEA:Intravenous injection of placebo (normal saline of 4mL) started immediately before surgery and continued for 3 days after surgery
Sponsors
Zhongshan Hospital affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing laparotomy for digestive system tumor surgery under general anesthesia combined with epidural block; 2. Aged 65 to 80 years old; 3. ASA I~II grade; 4. The study was examined by the ethics committee and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. There are contraindications to epidural anesthesia 2. History of chronic pain 3. History of mental illness 4. Definite diagnosis of heart or vascular disease, renal insufficiency, liver insufficiency (alanine aminotransferase or alanine aminotransferase >40U/L); 5. With pregnancy; 6. Inability to communicate; 7. Participated in other clinical studies within three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of chronic pain 3 months after surgery;Pain score of patients with chronic pain 3 months after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual analogue scale (VAS) score of pain at rest and cough within 72h after operation;PCA compression times and dosage within 72 hours after operation;Postoperative nausea and vomiting (PONV) degree;perioperative inflammation index changes including leukocyte count, neutrophil count, lymphocyte count, prothrombin time, activated clotting time live enzymes, high sensitive c-reactive protein and tumor necrosis factor and interleukin 1 beta, interleukin 2 receptor, interleukin 6 and interleukin 8, interleukin 10; | — |
Countries
China
Contacts
Public ContactGe Shengjin
Zhongshan Hospital affiliated to Fudan University
Outcome results
None listed