Sjogren's syndrome
Conditions
Interventions
Gold Standard:According to the clinical manifestations, chest imaging (cell-like change, ground glass change, solid shadow, mesh shadow), lung ventilation and diffusion function (FVC, DLCO), pathologi
Index test:miRNA-29
Sponsors
Tongji Hosipital, Tongji University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. To provide informed consent and voluntarily to provide information and venous blood needed for research; 2. Aged >=18 years; 3. Clinical diagnosis: pSS, PSS-ILD and IPF were met respectively. 4. Life expectancy >= 6 months.
Exclusion criteria
Exclusion criteria: 1. The cardiovascular system, respiratory system, endocrine system, blood system, immune system and other serious diseases are difficult to control; 2. Pregnancy or lactation; 3. Confirmed or suspected malignant tumor; 4. Severe neurological impairment caused by brain injury and cognitive impairment or dementia; 5. Suffer from serious mental illness; 6. Patients in the acute exacerbation of interstitial lung disease; 7. Researchers believe that there are other circumstances unsuitable for study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| miRNA-29;SEN, SPE, ACC, AUC of ROC; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lung High Resolution CT (HRCT) score;Diffusion capacity for carbon monoxide of lung (DLCO);Forced vital capacity, FVC;Arterial blood gas analysis;Dyspnea score;Cough symptom score; | — |
Countries
China
Contacts
Public ContactWang Xuan
Tongji Hosipital, Tongji University School of Medicine
Outcome results
None listed