Osteoarthritis of the knee
Conditions
Interventions
A:Preoperative analgesia was started 48 hours before surgery. Celecoxib was taken orally 200mg every time, once every 12 hours, and the last time was taken orally one hour before surgery.
B:Pre-operative analgesia was started 24 hours before surgery. Celecoxib was taken orally at 200mg each time, once every 12 hours, and the last time was taken orally one hour before surgery
C:Preoperative analgesia was started 1 hour before surgery, with 400mg of celecoxib administered orally
Sponsors
Department of Orthopaedics Surgery, West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. patients requiring unilateral initial TKA surgery due to severe knee osteoarthritis; 2. aged 40 to 80 years; 3. body mass index was 20~35 kg/m2; 4. the American Society of Anesthesiologists (ASA) classification (anesthesia risk assessment) I ~ III.
Exclusion criteria
Exclusion criteria: 1. Allergic to drugs used in this study; 2. there were more than moderate intraoperative knee malformations (pronation and flexion malformations) and joint stiffness; 3. alcoholic or long-term opioid users; 4. language impairment and inability to perform pain numerical scales (NRS); 5. surgical limb neuropathy; 6. mental patients; 7. patients with previous gastrointestinal ulcer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative dosage of remedial morphine hydrochloride;VAS pain score;Range of knee motion;Quadriceps strength;Daily walking distance;Incidence of postoperative complications;Time to first straight leg raise;The duration of hospital stay; | — |
Countries
China
Contacts
Public ContactPengde Kang
West China Hospital, Sichuan University
Outcome results
None listed