acute heart failure
Conditions
Interventions
experimental group:Sacubatril/valsartan
Sponsors
Zhongshan Hospital Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients who had not used Arnis before and were first admitted or readmitted due to acute heart failure (acute heart failure patients with acute heart failure as the first manifestation without previous chronic heart failure basis) or acute exacerbation of chronic heart failure; (2) All patients were heart failure (hfref) patients with reduced ejection fraction, i.e., LVEF < 40% (3) There are clinical manifestations of acute cardiac insufficiency, such as: the new lung moist rales or the original lung moist rales range increased compared with the previous, paroxysmal dyspnea at night, sitting up breathing, etc., and obvious activity tolerance decreased; (4) They should be over 18 years old, have complete behavioral ability, and be able to fully understand and sign the informed consent form; (5) New York Heart Function Classification (NYHA) grade II-IV.
Exclusion criteria
Exclusion criteria: (1) Patients who had been treated with Arnis for a long time and were readmitted for heart failure; (2) Non hospitalized patients with heart failure (outpatient follow-up); (3) Systolic blood pressure is lower than 90mmHg; (4) According to C-G formula, EGFR is lower than 30ml / min / 1.73m2 (because it is reported that this formula is more suitable for Asian population); (5) 5 mmol / L; (6) Previous use of ACEI / ARB had intolerance: angioneurotic edema, repeated dry cough excluded from other causes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NT-proBNP;sST2;LVEF; | — |
Secondary
| Measure | Time frame |
|---|---|
| LVEDV/LVESV;6mwt;KCCQ scale; | — |
Countries
China
Contacts
Public ContactChen Ruizhen
Zhongshan Hospital Fudan University
Outcome results
None listed