liver cancer
Conditions
Interventions
Case series:Radiofrequency ablation of liver lesions
Local immune drug PD-1 was injected into liver lesions
Oral administration of the antivascular-targeting drug Eitan
Sponsors
The Second Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) 18-75 years old; (2) HCC was confirmed by pathological examination; (3) Liver lesions that can be assessed by imaging; (4) BCLC stage: B-C; (4) Child-pugh classification: A-B; (5) ECOG PS: 0-2 marks; (6) Previous or no HCC treatment; (7) Sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Contraindications to radiofrequency ablation; (2) A history of allergy to PD-1 antibody; (3) HIV positive; (4) The presence of autoimmune diseases; (5) With a severe infection or serious underlying disease, such as hemorrhagic peptic ulcer, ileus, heart failure, renal failure or poorly controlled diabetes; (6) Failure to comply with the test requirements; (7) Pregnancy (confirmed by serum or urine human chorionic gonadotropin [-HCG]) or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OS;lesions size; | — |
Countries
China
Contacts
Public ContactWeixi Shen
The Second Affliated Hospital of Harbin Medical University
Outcome results
None listed