liver metastases
Conditions
Interventions
Group 1:Pd-1 antibody was injected into liver metastases
Group 2: Pd-1 antibody was injected into liver metastases
Sponsors
The Second Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) In patients with clinically confirmed liver metastasis from advanced malignant tumor, there is at least one measurable lesion in the liver, the size of the lesion & LT;5cm, number of lesions 3 months; (4) No recent new cardiovascular and cerebrovascular diseases, hemorrhagic diseases and other clinical emergencies ; (5) Liver function Child grade A or B; (6) Informed consent.
Exclusion criteria
Exclusion criteria: (1) A history of allergy to PD-1 antibody; (2) Contraindications to RFA; (3) The HIV positive; (4) Autoimmune diseases; (5) With a severe infection or underlying disease, such as hemorrhagic peptic ulcer, ileus, heart failure, kidney failure, or poorly controlled diabetes; (6) Failure to comply with the test requirements; (7) Pregnancy (confirmed by serum or urine human chorionic gonadotropin [-HCG]) or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ORR; | — |
Secondary
| Measure | Time frame |
|---|---|
| PFS;OS; | — |
Countries
China
Contacts
Public ContactTao Xin
The Second Affliated Hospital of Harbin Medical University
Outcome results
None listed