Skin Rash Induced by Anti-tumor Targeted Drugs
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Zhejiang Chinese Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Male or female patients aged >18 years; 2. Patients receiving anti-tumor targeted drugs; 3. Grade III rash according to NCI-CTC 5.0 standard; 4. KPS > 60, life expectancy >=3 months; 5. The functional level of major organs met the following criteria: 1) ANC (>= 1.5 *10^9/L), PLT (>= 75 *10^9/L), Hb (>= 80 g/L); 2) TBIL =50 ml/min) (Cockcroft-Gault formula); 6. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Skin lesions or skin diseases considered to affect the study, or history of allergic contact with other drugs; 2. Received hormones or antibiotics or any other drugs that may affect the skin rash within 1 week before the start of our research, including Chinese patent medicine and herbal medicine; 3. Serious or uncontrollable systemic diseases (such as unstable respiration, circulation, digestion, urinary and blood system diseases, ect.); 4. Previous history of neurological or mental disorders, including epilepsy and dementia; 5. Pregnancy or lactation; 6. The subject was considered not be able to complete the study or comply with the requirements of this study (due to management or other reasons).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes of rash classification;Effective time;Total effective rate;Cure rate;Partial response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Recurrence rate;Quality of life assessment;Safety evaluation;Completion rate of original anti-tumor treatment intensity; | — |
Countries
China
Contacts
Public ContactQijin Shu
The First Affiliated Hospital of Zhejiang Chinese Medical University
Outcome results
None listed