metallo-beta-lactamase producing carbapenem-resistant Entrobacteriaceae blood stream infection
Conditions
Interventions
polymyxin B +tigecycline:polymyxin B + tigecycline
Sponsors
Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with a clinical diagnosis of blood stream infection, and blood culture revealed MBL-CRE or high suspect of MBL-CRE infection; 2. Inpatients aged >= 18; 3. Female at child-bearing age with negative blood HCG test and willing to take contraceptives; 4. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Systemic use of antibiotics susceptive to MBL-CRE more than 48 hours in 72 hours before inclusion; 2. Ccr below 50 mL/min; 3. ALT level above 5-fold high criteria, or TBL level above 3-fold high criteria; 4. Glasgow score <= 8, or expect life less than 1 month; 5. Allergy to polymyxin B or tigecycline; 6. Included in another trial in 3 months, 7. Pregnant or feeding woman; 8. Patient can not follow the study schedual; 9. Patient who's inclusion will affect safety or data quality; 10. History of epilepsy or myasthenia gravis; 11. Patient not able to sampling continuously; 12. Co-use nephrotoxic drug when inclusion or high possible during study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pharmacokinetic parameters;efficacy;safety; | — |
Countries
China
Contacts
Public ContactYu Yunsong
Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University
Outcome results
None listed