polycystic ovary syndrome
Conditions
Interventions
Group A:Letrozole will be taken on the 3rd to 7th day of menstrual cycle, recombinant follicle stimulating hormone will be injected on the 7th to 11th day
Group B:Recombinant follicle stimulating hormone will be injected from the 3rd day of the menstrual cycle, the frequency and dosage will be adjusted according to the growth of follicles
Sponsors
The Third Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
Female
Age
18 Years to 42 Years
Inclusion criteria
Inclusion criteria: 1. Patients with PCOS who wish to conceive. The diagnostic criteria for PCOS are as follows (Rotterdam criteria): (1) oligoovulation or anovulation; (2) clinical manifestations of hyperandrogen and/or hyperandrogenemia; (3) ovarian polycystic changes. 2. Aged 18-42 years. 3. At least one unobstructed fallopian tube and normal uterine cavity. 4. Willing to sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications to assisted reproductive technology or pregnancy contraindications: such as uncontrolled diabetes, uncontrolled hypertension, heart disease, endometrial cancer, breast cancer, and unclearly diagnosed vaginal bleeding. 2. All male factors leading to infertility. 3. Urine and/or blood human chorionic gonadotropin test positive. 4. History of pregnancy (abortion or childbirth) within 12 months. 5. Abnormal uterine cavity. 6. History of repeated miscarriages. 7. Moderate or severe endometriosis. 8. Moderate or severe hydrosalpinx. 9. One of the husband and wife has abnormal chromosomes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cumulative single live birth rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| clinical pregnancy rate;miscarriage rate;multiple pregnancy rate;ongoing pregnancy rate;cycle cancellation rate;single follicle rate;rate of OHSS; | — |
Countries
China
Contacts
Public ContactYichun Guan
The Third Affiliated Hospital of Zhengzhou University
Outcome results
None listed