lung cancer
Conditions
Interventions
Single arm optimization strategy group:Multi objective optimization of IMRT strategy for lung volume and dose parameters
Sponsors
The Fifth Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
No minimum to 75 Years
Inclusion criteria
Inclusion criteria: (1) All patients were diagnosed as primary lung cancer by pathology or cytology, and had clear indications for radiotherapy; (2) ECOG physical performance status (PS) score 0~2 points, aged = 3 months. (6) Patients must meet all the following conditions: white blood cell count between 4,000 and 10,000/mm3; neutrophil count >= 2,000/mm3; platelet count >= 100,000/mm3; hemoglobin >= 11.0g/dL; aspartate aminotransferase (AST) and gluten Alanine aminotransferase (ALT) <= 1.5 times the upper limit of normal; total bilirubin <= 24umol/L and blood creatinine <= 85umol/L.
Exclusion criteria
Exclusion criteria: (1) Have received chest radiotherapy; (2) Those who cannot tolerate radiotherapy or stop radiotherapy for more than 1 week in the middle of radiotherapy; (3) The following serious diseases: uncontrollable infections, severe heart failure and myocardial infarction that have occurred in the past 6 months; (4) Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective efficacy (lesion size);Incidence and severity of radiation pneumonitis;Local control rate of local lesions;3-year, 5-year OS; | — |
Secondary
| Measure | Time frame |
|---|---|
| laboratory examination (blood routine, liver function, renal function, etc.);Adverse event; | — |
Countries
China
Contacts
Public ContactZibin Liang
Department of Thoracic Oncology, the Cancer Center of the Fifth Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed