Obstructive sleep apnea
Conditions
Interventions
experimental group:low-carbohydrate diet plus CPAP
Sponsors
Guangdong Provincial People's Hospital / Guangdong Academy of Medical Sciences / Guangdong Institute of Geriatrics
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged from 18 to 65 years old, both male and female; 2. Patients with BMI > 25 kg / m2; 3. Patients treated with CPAP for more than one year; 4. Reexamination AHI >= 15 / h without CPAP.
Exclusion criteria
Exclusion criteria: 1. Patients who had standardized weight loss plan 3 months before enrollment, such as weight loss surgery, drug weight loss, etc.; 2. Patients with central sleep apnea accounted for more than 20%; 3. Patients with diabetes mellitus or recurrent gout attacks; 4. Patients with eating disorders or extensive food allergy history; 5. Patients with serious primary heart, liver, kidney and blood system diseases or serious diseases affecting their survival, such as tumor, AIDS, renal dysfunction, cerebral hemorrhage, etc., have a history of surgery in the past year; 6. Subjects with irregular lifestyle in recent three months, such as frequent business trip, social intercourse and night shift, and more than two times a week; 7. Those who are expected to be unable to avoid frequent night shift or business trip in the next three months; 8. Patients with anxiety, depression, mental disorders and other diseases (by case and medication history); 9. Pregnancy, lactation, pregnancy preparation objects; 10. The researcher thinks it is not suitable to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Apnea Hyponea Index, AHI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Epworth Sleepiness Scale, ESS;Insomnia Severity Index, ISI;Pittsburgh sleep quality index, PSQI;weight;neck circumference;Waist-hip ratio;body fat rate (%);body fat mass (FM);muscle mas;basal metabolic rate (BMR);visceral fat rating;average oxygen saturation at night;Minimum oxygen saturation at night;sleep efficiency;REM sleep percentage;Oxygen Desaturation Index, ODI;arousal index;APAP treatment pressure;high density lipoprotein (HDL);low density lipoprotein (LDL);Total Cholesterol (TC);glucose;Fasting insulin;liver and kidney function indexes;tumor index;lateral cephalometric radiographs;intestinal flora;oropharyngeal flora;facial images;leptin;Orexin;Dietary structure;energy intake; | — |
Countries
China
Contacts
Public ContactOu Qiong
Guangdong Provincial People's Hospital / Guangdong Academy of Medical Sciences / Guangdong Institute of Geriatrics
Outcome results
None listed