CircRNA expression profile, effect and mechanism of hyperbaric oxygen for early cognitive decline after acute ischemic stroke

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000035074

Enrollment

Unknown

Registered

2020-07-30

Start date

2020-09-01

Completion date

Unknown

Last updated

2020-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ischemic stroke

Interventions

Experimental group:hyperbaric oxygen therapy

the control group:conventional drugs, rehabilitation therapy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1) Acute ischemic stroke (first onset) was diagnosed by two or more specialists; (2) Onset time <= 8 days; (3) Right-handed; (4) Complete imaging data; (5) The diagnostic criteria of early cognitive decline after ischemic stroke refer to the criteria of vascular cognitive impairment in 2019 Chinese Guidelines for the Diagnosis and Treatment of Vascular Cognitive Impairment.

Exclusion criteria

Exclusion criteria: (1) Combined with other non-vascular causes of neural function defects; (2) Due to various symptoms (including impaired consciousness, inability to communicate, language impairment, severe post-stroke depression, etc.), the evaluation could not be completed; (3) Have a clear history of cognitive impairment or mental illness. (4) Patietns enrolled in early cognitive decline group need to exclude the hyperbaric oxygen treatment contra.

Design outcomes

Primary

Measure	Time frame
circRNA;	—

Secondary

Measure	Time frame
microRNA;BDNF;	—

Countries

China

Contacts

Public ContactQi Fang

The First Affiliated Hospital of Sochow University

fangqi_008@126.com+86 13606213892

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026