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Effect of triptorelin acetate combined with letrozole on pregnancy outcome of frozen thawed embryo transfer in patients with repeated implantation failure: a randomized controlled trial.

Effect of triptorelin acetate combined with letrozole on pregnancy outcome of frozen thawed embryo transfer in patients with repeated implantation failure

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000035030
Enrollment
Unknown
Registered
2020-07-28
Start date
2020-08-01
Completion date
Unknown
Last updated
2020-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Interventions

1:GnRH-a+letrozole+FET
2:GnRH-a+FET
3:HRT-FET

Sponsors

Northwest children’s and women’s hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: The remaining frozen embryos were to be feted again. RIF is defined as: 1. Patients with at least two failed embryo transfer cycles (including fresh cycles and freeze-thaw cycles); 2. Or the number of transferred embryos > 10 / high-quality embryos > 6 / high-quality blastocysts > 2 have not yet obtained clinical pregnancy; 3. Or in the failure cycle, the transferred embryos were of high quality (>= 4 grade I and II cleavage stage embryos or > 2 high quality blastocysts (3bC / 3CB or above).

Exclusion criteria

Exclusion criteria: 1. Patients with uterine malformation or endometrial organic lesions; 2. Patients with uterine fibroids and adenomyosis with endometrial compression; 3. Patients with history of intrauterine adhesions; 4. Patients with chromosomal abnormalities in one or both sides; 5. Patients with thyroid disease or uncontrolled diabetes and other endocrine diseases; 6. Patients with antiphospholipid syndrome or other thrombophilic states.

Design outcomes

Primary

MeasureTime frame
ongoing pregnancy rate;

Secondary

MeasureTime frame
Clinical pregnancy rate;

Countries

China

Contacts

Public ContactShi Juanzi

Northwest Women's and Children's Hospital

shijuanziart@126.com+86 13087519216

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026