Tonsillar and adenoidal hypertrophy
Conditions
Interventions
group A20 :Low-dose alfentanil
group A40:medium-dose alfentanil
group A60:high-dose Alfentanil
Sponsors
The Second Affiliated Hospital of Wenzhou Medical University/ Yuying Children's Hospital
Eligibility
Sex/Gender
All
Age
4 Years to 7 Years
Inclusion criteria
Inclusion criteria: 1. Informed consent was signed by the family members of the subjects; 2. Subjects aged 4-7 years; 3. Subjects of ASA grade I-II; 4. Subjects with body weight greater than 14 kg but less than 26 kg; 5. Those who need tonsillectomy under general anesthesia; 6. Subjects with normal or abnormal laboratory and imaging results but no clinical significance.
Exclusion criteria
Exclusion criteria: 1. Patients with allergic history of general anesthesia drugs; 2. Patients who have taken analgesics, sedatives or other psychoactive drugs in the past two weeks; 3. Patients with history of upper respiratory tract infection in recent 6 weeks; 4. Patients with history of reactive airway diseases; 5. Patients with suspected difficult airway; 6. Patients with neuromuscular diseases; 7. Patients with impaired liver and kidney function; 8. Patients with metabolic diseases; 9. Patients who have participated in other drug trials within 3 months; 10. Patients who are considered ineligible for any reason by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Helbo-Hansen Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;Blood pressure;Pulse oxygen saturation;MAC;Spontaneous breathing recovery time;Extubation time;Eye open time;Total observation time of PACU;VAS score;Ramsay sedation score;Agitation score; | — |
Countries
China
Contacts
Public ContactWangning Shangguan
The Second Affiliated Hospital of Wenzhou Medical University/ Yuying children's Hospital
Outcome results
None listed