Postoperative cognitive dysfunction
Conditions
Interventions
Remote preconditioning group:Remote ischemic preconditioning
Control group:Cuff compression but no ischemic preconditioning
Sham group:Nil
Sponsors
Xijing Hospital of Air Force Military Medical University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. From July 2020, Xijing Hospital of Air Force Military Medical University admitted patients who were scheduled to undergo surgery under general anesthesia; 2. Patients with operation time >= 2 h; 3. Patients aged over 60 years old; 4. American Society of anesthesiologists (ASA): Grade II ~ III; 5. Patients who have signed informed consent form; 6. The non-surgical control group was age and gender matched non-surgical outpatients in the same period.
Exclusion criteria
Exclusion criteria: 1. Patients with degenerative diseases of central nervous system, including dementia, Alzheimer's disease and Parkinson's disease; 2. Neurobehavioral assessment was performed within three months; 3. Patients with mental illness who need treatment; 4. Mini Mental State Examination MMSE 2 mg / dl, i.e. 176.82 µ mol / L); 9. Patients with liver diseases (AST, ALT 1.5 times higher than the normal upper limit); 10. Patients who are unable to comply with or unwilling to cooperate; 11. Patients who are unable to complete the procedure according to instructions; 12. Patients with unclear understanding of the language used in the study; 13. Patients with severe visual or hearing impairment; 14. Patients with alcohol or drug dependence (drinking more than 5u a day in the past three months, 1U is equal to 10ml or 8g pure alcohol, equivalent to more than 100ml of liquor of > 50 degree, two liang); 15. Patients who have participated in this study or other clinical studies at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| POCD incidence;Serum MD2 and CystatinC levels;The relative risk of allelic locus mutations and POCD; | — |
Secondary
| Measure | Time frame |
|---|---|
| The variability of the methylation gene sequencing of the target region of the patient's nucleic acid level; | — |
Countries
China
Contacts
Public ContactHailong Dong
Department of Anesthesia and Perioperative Medicine, Xijing Hospital of Air Force Military Medical University
Outcome results
None listed