Cognitive dysfunction, Alzheimer's disease, sarcopenia, weakness, disability, etc.
Conditions
Interventions
Control group:health education
Intervention group:Joint intervention (exercise + nutrition + cognitive training)
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
65 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. A community resident between 65-75 years old (based on ID card); 2. The chief complaint of forgetfulness (self-reported memory has deteriorated in the past five years), or memory deterioration confirmed by himself or his accompany during interviews; 3. Baseline MoCA score 24; 4. Lawton and Brody daily tool activity scale score > 6/8; 5. Education: graduated from high school and above; 6. Living in your own home instead of hospital or long-term care Institutions; 7. Visual and auditory: you can read and write by yourself; 8. Do not take anti-dementia drugs (such as donepezil, galantamine, etc.) in the near future or during the research period; 9. Sign the informed consent form to confirm that all participants have been informed of the trial Related content; 10. Able to walk 4 meters independently with or without a walker; PAR-Q + scale evaluation confirmed that the health status of the subjects has reached the level of participating in the relevant exercises of the experiment.
Exclusion criteria
Exclusion criteria: 1. During the 3 months prior to entering the study, they were engaged in moderate 2 degree exercise (such as brisk walking) for more than 60 minutes per week; 2. Diagnosed with any type of dementia; 3. Clinically suspected of having neurodegenerative diseases (eg, multiple sclerosis, Parkinson's disease, Huntington's disease, frontotemporal dementia), Instead of Alzheimers disease, vascular cognitive impairment, which causes cognitive impairment; 4. There is a high risk of adverse cardiovascular events during exercise, or it is unable to adjust activities according to the guidance of rehabilitation exercise experts or fail to pass Understand to reach the recommended level of activity; 5. Diagnosed with severe peripheral neuropathy or severe musculoskeletal or joint disease that impairs mobility; 6. Taking drugs that may have a negative impact on cognitive function, such as anticholinergic drugs, including Drugs with obvious anticholinergic properties (such as amitriptyline), main sedatives (ie typical and atypical antipsychotics) and anticonvulsants (such as gabapentin, sodium valproate); 7. Within the last 24 months Any hormonal therapy (estrogen, progesterone or testosterone) received; 8. Plan to participate in or have participated in a synchronized clinical drug or exercise test; 9. Elderly persons with metal in the body, including dentures (not removable), cardiac pacemakers, Artificial hip joints, steel plates, steel nails, brackets and other metals, so as not to affect the fMRI test results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fMRI;step speed;Hand grip;BIA;Chair-sit-up-test; | — |
Countries
China
Contacts
Public ContactBirong Dong
West China Hospital of Sichuan University
Outcome results
None listed