pulmonary hypertension
Conditions
Interventions
BPA:BPA
Target Drug:Target Drug
BPA+Target Drug:BPA+Target Drug
Sponsors
The First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. It meets the diagnostic criteria of CTEPH, multidisciplinary assessment is not suitable for PEA treatment, and WHO cardiac function grades II to III; 2. Aged 20 to 80 years old; 3. Mean pulmonary artery pressure 25 to 60 mmHg and pulmonary artery wedge pressure (PAWP) <=15 mmHg; 4. At least 3 months of standard anticoagulant therapy (INR was controlled at 1.5–3.0 for warfarin); 5. Written informed consent was provided to fully explain the consent to participate in the study.
Exclusion criteria
Exclusion criteria: 1. Previous BPA treatment; 2. Use vasodilators within 4 weeks before right heart catheterization; 3. Combined with other diseases that can cause pulmonary hypertension; 4. Pregnancy or breastfeeding; 5. Contraindications to targeted drugs or contrast agents; 6. Researchers think it is not suitable to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pulmonary perfusion quantitative indexes;:right heart catheterization indexes;echocardiography indexes;Cardiopulmonary exercise testing indexes;N-terminal pro-Brain Natriuretic Peptide; | — |
Secondary
| Measure | Time frame |
|---|---|
| 6-minute walk distance;Borg dyspnea indexes;WHO functional class;Quality of life; | — |
Countries
China
Contacts
Public ContactCheng Hong
The First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed