Obstructive azoospermia
Conditions
Interventions
Testicular spermatozoa group:The spermatozoa are aspirated from testis by puncturing
Epididymal sperm group:The spermatozoa are aspirated from epididymis by puncturing
Sponsors
The Third Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
Male
Age
22 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1) Informed consent has been signed before enrollment; 2) The patient was clearly diagnosed as obstructive azoospermia, and more than one moving sperm /HPF are observed in epididymal puncture; 3) Patients are aged 22-40 years and going to be treated with ICSI; 4) The spouse are aged 20-35 years old with 3-20 eggs; 5) It is the first ICSI cycle of the subject.
Exclusion criteria
Exclusion criteria: 1) Couples planning to freeze all embryos due to hydrosalpinx requiring surgical treatment or high progesterone level on HCG day; 2) There are factors affecting the outcome of ICSI in the female, including but not limited to grade III-IV endometriosis, visible hydrosalpinx under B-ultrasound, recurrent abortion history; 3) Couples with known abnormal chromosomal karyotypes; 4) Couples diagnosed with any systemic disease with clinical symptoms; 5) Other IVF/ICSI contraindications; 6) The spouse is diagnosed with abnormal uterine morphology (confirmed by three-dimensional B-ultrasound or hysteroscopy), including uterine malformation (mediastinal uterus, single angle or double uterus), submucosal uterine fibroids or intramural myoma (greater than 5cm), or intrauterine adhesion; 7) IVM, egg-freezing, or PGT cycles; 8) The patient is currently participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Live birth rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fertilization rate;Day 3 egg utilization rate;Implantation rate;Clinical pregnancy rate;Pregnancy loss rate;Neonatal birth weight;Sperm retrieval rate;Sex ratio at birth; | — |
Countries
China
Contacts
Public ContactGeng An
The Third Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed