Acute Ischemic Stroke
Conditions
Interventions
Experimental group:Adjust insulin dosage according to arterial blood gas analysis blood glucose level
Control Group:Adjust insulin dosage according to peripheral blood glucose level
Sponsors
Southern Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients who voluntarily sign informed consent form; 2. Patients aged 18-70 years, regardless of gender; 3. For patients with stress hyperglycemia during NICU hospitalization, SIH was defined as the ratio of serum glucose to estimated mean blood glucose at admission. SIH was defined as the ratio > 1.1. The average blood glucose estimate was calculated as [(28.7 x HbA1c) - 46.7] / 18mmol / L. 4. Patients with baseline NIHSS score = 4 and = 25; (1) The patients who received enteral nutrition through nasogastric tube or nasointestinal tube continuous nutrition pump; (2) Patients with invasive arterial blood pressure were monitored by catheterization via radial or brachial artery; (3) Patients who are expected to stay in NICU for more than 5 days; (4) When patients meet any one or more of the following: shock, use of vasoactive drugs, plasma exchange or hemodialysis, systemic edema (especially finger tip and earlobe), continuous 24-hour insulin infusion for more than 5 days, and peripheral blood glucose = 3.9 mmol / L.
Exclusion criteria
Exclusion criteria: 1. Patients with severe cardiopulmonary liver and kidney dysfunction indicated by admission examination or medical history; 2. Patients with blood examination and ketoacidosis or hyperglycemia coma diagnosed by doctors; 3. Female patients in pregnancy or lactation, patients with brain death; 4. Patients who have used drugs that may affect glucose metabolism one month before the study and in the trial, such as glucocorticoids, thyroid hormones, thiazide diuretics, etc; 5. Patients with exogenous insulin allergy; 6. Patients who have participated in other intervention studies; 7. Patients with life expectancy less than 3 months unrelated to the stroke.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hyperglycemia Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| glycemic lability index;The incidence of increased cerebral infarction volume or new infarcts;The incidence of hemorrhagic transformation after ischemic stroke;The incidence of hypoglycemia(Glucose<3.9mmol/l); | — |
Countries
China
Contacts
Public ContactZhang Xiaomei
Southern Hospital of Southern Medical University
Outcome results
None listed