sepsis, acute gastrointestinal injury
Conditions
Interventions
trial group:Berberine + compound B vitamin
control group:compound B vitamin
Sponsors
Shenzhen Second People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Hospitalized patients aged >= 18 years and less than 80 years. 2. Meet the diagnostic criteria of septic shock in the 2016 guidelines for the treatment of severe infection and septic shock, that is to say, sepsis is diagnosed with persistent hypotension, and even after adequate volume resuscitation treatment, hypertension drugs are required to maintain MAP >= 65mmHg and blood lactate level > 2mmol/L (18mg/dl). 3. AGI diagnostic and quantitative scoring criteria for acute gastrointestinal injury were met.
Exclusion criteria
Exclusion criteria: 1. Acute central nervous system diseases (stroke, traumatic brain injury); 2. Severe abdominal trauma; 3. Acute myocardial infarction, severe arrhythmia, heart failure and shock (IABP), cardiopulmonary resuscitation; 4. Primary neuromuscular lesions; 5. Drug, alcohol, opioid or amphetamine dependence, mental disorders; 6. Maternal; 7. Advanced malignant tumor or malignant fluid or terminal chronic disease; 8. Death is expected within ICU 24h; 9. Previous berberine allergy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AGI graded mitigation; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day mortality rate;60-Day mortality rate;inflammation;Blood coagulation; | — |
Countries
China
Contacts
Public ContactMing Wu
Shenzhen Second People's Hospital
Outcome results
None listed