A randomized control trial for zoledronic acid treatment in adult necrosis of femoral head

Zoledronic acid for adult necrosis of femoral head: a randomized controlled trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000034931

Enrollment

Unknown

Registered

2020-07-24

Start date

2020-07-20

Completion date

Unknown

Last updated

2020-07-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

necrosis of femoral head

Interventions

experimental group:zoledronic acid and basic treatment (drilling decompression, aspirin, calcitriol, celecoxib)

control group:basic treatment

Eligibility

Sex/Gender

All

Age

20 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Patients who diagnosed with non-traumatic early-stage necrosis of femoral head; 2. Patients with age more than 20 years; 3. Patients who are willing to participate in this study.

Exclusion criteria

Exclusion criteria: 1. Previous surgery on ipsilateral hip; 2. Pregnant and lactating women or female in the preparation of fertility; 3. Patients with hypercalcemia; 4. Patients with dysfunction of liver or kidney; 5. Patients associated with tumor.

Design outcomes

Primary

Measure	Time frame
collapse rate of femoral head;outcome of necrotic foci in non-collapsed cases;The completion or needed completion rate for surgery;	—

Secondary

Measure	Time frame
Harris score;SF12 score;25(OH)D;Carboxy-terminal peptide of type I collagen;bone alkaline phosphatase;Serum osteocalcin N - terminal fragment;	—

Countries

China

Contacts

Public ContactXiaojun Shi

West China Hospital of Sichuan University

shixjoint@scu.edu.cn+86 18980606872

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026