Mechanism of Citrate/NLRP3/IL-1ß-mediated Macrophage Classic Polarization in Impaired Wound Healing in Diabetes

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2000034897

Enrollment

Unknown

Registered

2020-07-23

Start date

2021-01-01

Completion date

Unknown

Last updated

2020-07-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic wound

Interventions

non-diabetic wound group vs diabetic wound group:Nil

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Control group: the subjects were non-diabetic patients with wound, except for organic heart disease, without hyperlipidemia, type 2 diabetes, obesity, gout, silicosis, Alzheimer's disease and Crohn's disease. 2. Diabetic wound group: Patients with diabetic wound.

Exclusion criteria

Exclusion criteria: 1. Skin ulcer caused by electricity, chemistry and radioactivity; 2. Patients with chronic and severe heart, liver and kidney dysfunction; 3. Patients diagnosed as malignant tumor; 4. Doctors think it is not suitable for this study or have not signed the informed consent form; 5. Mental retardation, extreme alcoholism and drug abuse history; 6. Pregnant, intending or lactating women.

Design outcomes

Primary

Measure	Time frame
Expression of citrate and related inflammatory factors;	—

Countries

China

Contacts

Public ContactDai Jiezhi

Shanghai Jiaotong University Affiliated Sixth People's Hospital

daijiezhi@aliyun.com+86 18930170171

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026