Type 2 diabetes
Conditions
Interventions
trial group:Insulin treatment + nutritional dietary intervention
control group:Insulin treatment + diet education g
Sponsors
He'nan Provincial People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients with type 2 diabetes diagnosed according to the above criteria for less than 10 years, and 6.5% (2) The age is 18-65 years (age is calculated according to the difference between the screening survey date and the date of birth); (3) Have lived in the local area for at least 5 years and have a fixed residence; (4) Currently, I have not participated in other research projects; (5) Good memory and activity ability; (6) Be mentally healthy and able to take care of themselves; (7) Sign the informed consent; (8) Those with good compliance have an urgent desire to change their physical conditions and fully understand the "enterogenic theory of chronic diseases".
Exclusion criteria
Exclusion criteria: (1) Patients with more than one positive diabetes antibody (IAA, ICA and GAD) and diagnosed with type 1 diabetes; (2) Patients with severe diabetic complications, such as diabetic foot, severe liver and kidney injury, severe neurological disease, and severe retinopathy; (3) Blood pressure >= 180/110mmhg, plasma triglyceride >= 2.3mmol/L, total cholesterol >= 6.2mmol/L; (4) Use of antibiotics in the past 3 months for a duration of 3 days or more; (5) Pregnant and lactating women; (6) Excessive drinking (more than 5 times a week, average 2 pairs of white wine or half a jin of yellow rice wine or more than 5 bottles of beer each time); (7) Has suffered from a serious mental illness in the past six months; (8) Patients receiving medical treatment for the following diseases in the past 3 months: cholecystitis, gastrointestinal ulcer, urinary tract infection, acute pyelonephritis, cystitis, hyperthyroidism and other thyroid dysfunction; (9) Gastrointestinal surgery, except appendicitis and hernia surgery; (10) Patients with chronic, protracted hepatitis or severe liver diseases such as cirrhosis, and hepatitis B virus surface antigen (HBsAg); positive patients with abnormal liver function (serum ALANINE aminotransferase and alanine aminotransferase are 2.5 times of normal value); (11) Patients with IBD and Cushing syndrome; (12) Abnormal pituitary function; (13) Serious organic diseases such as cancer, coronary heart disease, myocardial infarction and stroke; (14) suffering from infectious diseases such as tuberculosis and AIDS; (15) Unable to take care of themselves, remember clearly or answer questions due to physical disability or other reasons; (16) Anemia: hemoglobin < 10g/ dL; (17) Having obvious dyskinesia; (18) There is no guarantee of sufficient time to participate in the project.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glycosylated hemoglobin;Insulin dose;Composition and functional characteristics of gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dynamic glucose fluctuation; | — |
Countries
China
Contacts
Public ContactHuijuan Yuan
He'nan Provincial People's Hospital
Outcome results
None listed