Psoriasis
Conditions
Interventions
Psoriasis group:Methotrexate
healthy control group:Nil
Sponsors
Dermatological Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with moderate to severe psoriasis vulgaris; 2. Can receive long-term low-dose MTX treatment.
Exclusion criteria
Exclusion criteria: 1. Younger than 16 years of age; 2. Women who are pregnant or breastfeeding; 3. Those who have a birth control plan within the past 3 months; 4. Alcoholism; 5. People who have mental illness or are unable to cooperate with treatment; 6. Infectious diseases such as tuberculosis, etc. that are active at the same time; 7. Those with immunodeficiency; 8. Serious systemic diseases such as abnormal liver and kidney function, viral hepatitis or cirrhosis, liver transaminase, blood creatinine and urea nitrogen Those who exceed 1.5 times the upper limit of normal, blood system diseases (white blood cell count < 4 * 10^9/L, hemoglobin <80g/L, platelets < 100 * 10^9/L); 9. Hepatotoxicity in the past 3 months Drug users.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PASI score; | — |
Countries
China
Contacts
Public ContactHua Weiwei
Dermatological Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed