Infection of burn wound
Conditions
Interventions
30-50% burn area:Cilastatin Sodium
50-80% burn area:Cilastatin Sodium
More than 80% of the burn area:Cilastatin Sodium
Sponsors
The Second People's Hospital of Shenzhen
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-70 years, regardless of gender; 2. The total area of burn (flame burn, electric burn, chemical burn, all kinds of hot liquid scald) >= 30%; 3. Patients diagnosed as burn infection according to clinical manifestations, signs and etiological examination; 4. Patients who meet the clinical application of carbapenem antibiotics (severe infection caused by multi drug resistant but sensitive aerobic gram-negative bacilli; severe patients with mixed infection of anaerobic bacteria and aerobic bacteria such as Bacteroides fragilis; experience treatment for patients with severe immune deficiency whose pathogen has not been identified); 5. Patients with no history of mental illness; 6. Patients who did not receive antibiotic treatment within 2 days; 7. Patients who signed the consent form: all subjects voluntarily signed informed consent before the trial; 8. Patients who can persist in completing the treatment course.
Exclusion criteria
Exclusion criteria: 1. Patients allergic to imipenem and cilastatin sodium and other antibiotics; 2. Patients with renal insufficiency; 3. Pregnant women and patients with central nervous system diseases; 4. Patients with epilepsy and mental illness; 5. Patients who are participating in other clinical trials; 6. Patients who are considered unsuitable for clinical trials due to other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of wound infection in burn patients;Temperature drop in burn patients;The situation of tissue microbial culture in burn wound patients turned negative; | — |
Secondary
| Measure | Time frame |
|---|---|
| Observe the drug concentration of imipenem cilastatin sodium; | — |
Countries
China
Contacts
Public ContactWang Daoxin
The Second People's Hospital of Shenzhen
Outcome results
None listed