Metagenomic analysis of microbial diversity and antimicrobial effect of fluoride varnish in children's supragingival plaque

Metagenomic analysis of microbial diversity and antimicrobial effect of fluoride varnish in 3 yrs children's supragingival plaque

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000034847

Enrollment

Unknown

Registered

2020-07-21

Start date

2020-07-25

Completion date

Unknown

Last updated

2020-07-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

primary dental caries

Interventions

Carious group:Coating fluoride varnish for deciduous teeth

Healthy group:Coating fluoride varnish for deciduous teeth

Eligibility

Sex/Gender

All

Age

3 Years to 3 Years

Inclusion criteria

Inclusion criteria: 1. 3-year-old Han children who often live in Xi'an; 2. Complete deciduous dentition; 3. Be able to review on time.

Exclusion criteria

Exclusion criteria: 1. Enamel hypoplasia, dentin hypoplasia, etc.; 2. Congenital diseases or systemic diseases; 3. There are active bacterial and viral infections in other parts of the body; 4. Dental fluorosis preventive measures (such as fluoride foam, fluoride gel, fluorovarnish, etc.) and pit and fissure sealant were used for oral prophylactic treatment in 3 months. Antibiotics and immunosuppressive drugs were used in 1 months.

Design outcomes

Primary

Measure	Time frame
dmft;	—

Secondary

Measure	Time frame
Raw reads;OTUs number;Alpha diversity index;Beta diversity index;	—

Countries

China

Contacts

Public ContactWang Shengchao

School of Stomatology, the Fourth Military Medical University

wangshengchao@fmmu.edu+86 029-84776475

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026