Evaluation of the efficacy of intra-articular injection of umbilical cord blood PRP in patients with early knee arthritis: a prospective randomized controlled clinical trial

Evaluation of umbilical cord blood PRP in patients with early knee arthritis

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000034816

Enrollment

Unknown

Registered

2020-07-20

Start date

2020-08-01

Completion date

Unknown

Last updated

2020-07-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis

Interventions

A:Allogeneic cord blood PRP

B:Autovenous PRP

C:HA

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Ages 35 to 85 years; 2. Meet the 1995 Revision of the American Rheumatic Association classification criteria for Osteoarthritis of the Knee; 3. Kellgren-Lawrence (KL) Grade I~III; 4. The patient agrees to the treatment method and signs the informed consent.

Exclusion criteria

Exclusion criteria: 1. With systemic diseases such as diabetes, blood diseases, or local infections; 2. Hemoglobin <11 g/L, platelet < 1.5 *10^5/L; 3. There was a history of use of nsaids 5 days before treatment. 4. Those who took anticoagulants and immunosuppressants within 3 months.

Design outcomes

Primary

Measure	Time frame
Occurrence of adverse reactions;visual analogue scale, VAS;International Knee Documentation Committee, IKDC;Western Ontario and McMaster Universities Osteoarthritis Index, WOMAC;	—

Countries

China

Contacts

Public ContactLiu Wenguang

The Second Hospital, Cheeloo College of Medicine, Shandong University

2015120471@mail.sdu.edu.cn+86 13156013139

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026