Perioperative neurocognitive disorders
Conditions
Interventions
postoperative delirium group:Nil
Sponsors
The General Hospital of Northen Theater Command
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: NP group 1. Aged 18 years- 45 years ; 2. Subjects with BMI of 17.5-30.0kg/m2; 3. Those with education level >= junior high school; 4. Basic cognitive function was normal (MMSE score >= 27 and MOCA score >= 26); 5. Subjects without anxiety and depression (SAS / SDS score = 27 and MOCA score >= 26); 7. Patients without anxiety and depression (SAS / SDS score < 53); 8. Patients with postoperative delirium.
Exclusion criteria
Exclusion criteria: NP group 1. The object of rejection; 2. Subjects with a history of cognitive dysfunction; 3. Subjects with previous neurological and mental disorders; 4. Long term use of psychotropic drugs or continuous use of antibiotics for more than 3 days in recent 3 months; 5. Subjects with a history of stroke or other organic encephalopathy; 6. Those who are or have suffered from malignant tumor; 7. Patients with intestinal system function or organic diseases, such as irritable bowel syndrome, ulcerative colitis, etc. Group P: 1. The patient refused; 2. Patients who have been taking psychotropic drugs for a long time or taking antibiotics for more than 3 days in recent 3 months; 3. Patients with preoperative anxiety or delirium history; 4. Patients with previous neurological and mental disorders; 5. Patients with a history of stroke or other organic encephalopathy; 6. Patients who are or have been suffering from malignant tumor; 7. Patients with abnormal thyroid function, liver and kidney function; 8. Patients with intestinal system function or organic diseases, such as irritable bowel syndrome, ulcerative colitis, etc; 9. Patients with more blood loss (> 500ml) or receiving blood transfusion during operation; 10. Patients with hypoxemia (SpO2 < 90%) during perioperative period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function score;Metagenomic sequencing of fecal flora; | — |
Countries
China
Contacts
Public ContactSun Yingjie
North theater General Hospital
Outcome results
None listed