Infective endocarditis
Conditions
Interventions
Oral antibiotics:After his condition stabilized, he was discharged from hospital and treated with oral antibiotics
Continuous intravenous:Continuous intravenous therapy
Sponsors
Xiangya Hospital of Centre-south University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Endocarditis based on improved Duke criteria 1. Aged >= 18 years; 2. Generally >= 10 days of appropriate parenteral antibiotic therapy and at least 1 week of appropriate parenteral therapy after valve surgery; 3. Stable condition: body temperature below 38.0 degrees C & GT > 2 days; 4. C-reactive protein decreased to less than 25% of peak value during antibiotic treatment or & LT < 20 mg/L, WBC count & LT < 15 x 10^9 / L; 5. Echocardiography showed no signs of abscess formation; 6. Transthoracic and transesophageal echocardiography were performed within 48 hours prior to random assignment.
Exclusion criteria
Exclusion criteria: 1. Body mass index > 40; 2. With other site infection, intravenous antibiotics are required; 3. Failure to knowingly consent to participate; 4. Suspected reduction in oral absorption due to abdominal disease; 5. Low compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrence rate of bacteremia;All cause mortality;Incidence of unplanned cardiac surgery;incidence of thromboembolic events; | — |
Secondary
| Measure | Time frame |
|---|---|
| Treatment cost during hospitalization and follow-up; | — |
Countries
China
Contacts
Public ContactLuo Fanyan
Xiangya Hospital of Centre-South University
Outcome results
None listed