chronic hepatitis B
Conditions
Sponsors
Guangdong Provincial Hospital of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Part 1 (1) having a history of chronic hepatitis B. (2) Nucleoside (acid) antiviral treatment >= 24 weeks. (3) willing to cooperate with the study and sign the informed consent. Part 2 (1) having a history of chronic hepatitis B. (2) Age: 18-65 years old. (3) Nucleoside (acid) antiviral treatment >= 24 weeks. (4) combined with bone mineral density decreased. (5) willing to cooperate with the research and sign the informed consent.
Exclusion criteria
Exclusion criteria: Part 1 (1) With a definite history of chronic kidney disease or osteoporosis before antiviral therapy. (2) In addition to antiviral drugs, receiving kidney damage drugs or glucocorticoids that can lead to osteoporosis. (3) Pregnant or lactating women. Part 2 (1) With a definite history of chronic kidney disease or osteoporosis before antiviral therapy. (2) In addition to antiviral drugs, receiving kidney damage drugs or glucocorticoids that can lead to osteoporosis. (3) Co-infection with HAV, HCV, HDV, HEV or HIV. (4) Combined with pituitary, parathyroid and other diseases that affect calcium and phosphorus metabolism,or receiving drugs affecting calcium and phosphorus metabolism. (5) Combined with secondary liver disease caused by severe malnutrition, total parenteral nutrition, weight loss after bariatric surgery, drug, environmental or industrial toxicosis. (6) Combined with cardiovascular, brain, kidney and other serious organic diseases and severe primary diseases of hematopoietic system. (7) Patients with poor compliance and unable to adhere to treatment. (8) combined with liver cancer or cancers of other organs. (9) Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| eGFR;bone mineral density; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum calcium, serum phosphorus;HBsAg, HBeAg, HBVDNA;Characteristics of TCM Syndromes; | — |
Countries
China
Contacts
Public ContactXiaoling Chi
Guangdong Provincial Hospital of Chinese Medicine
Outcome results
None listed