Comparison of analgesic effect of continuous adductor tube block with different concentrations of dexmedetomidine combined with ropivacaine after total knee arthroplasty

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000034775

Enrollment

Unknown

Registered

2020-07-18

Start date

2020-07-13

Completion date

Unknown

Last updated

2020-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

TKA

Interventions

C:0.2% ropivacaine

D1:0.2% ropivacaine+0.5ug/ml dexmedetomidine

D2:0.2% ropivacaine+1.0ug/ml dexmedetomidine

D3:0.2% ropivacaine+1.5ug/ml dexmedetomidine

D4:0.2% ropivacaine+2.0ug/ml dexmedetomidine

Eligibility

Sex/Gender

All

Age

60 Years to 75 Years

Inclusion criteria

Inclusion criteria: A total of 200 patients undergoing elective TKA surgery were selected, regardless of sex, aged from 60 to 75 years, ASA I-III grade.

Exclusion criteria

Exclusion criteria: 1. Puncture site infection. 2. Coagulation dysfunction. 3. Diabetes mellitus complicated with peripheral neuropathy. 4. Severe cardiopulmonary dysfunction. 5. Sinus bradycardia. 6. Allergic to research drugs. 7. Mental illness patients with pain score and cognitive function changes.

Design outcomes

Primary

Measure	Time frame
Postoperative pain;	—

Secondary

Measure	Time frame
time to get out of bed;time of active knee flexion 90 degrees;times of self controlled administration and the number of cases with remedial analgesics within 48h postoperation;	—

Countries

China

Contacts

Public ContactPeng Shengliang

The Second Affiliated Hospital of Nanchang University

1361312648@qq.com+86 18770031160

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026