Laparoscopic abdominal surgery
Conditions
Interventions
experimental group:Different doses of nalmefen will be administered 10 minutes before anesthesia, and added to the PCIA
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 60~75 years; 2. ASA I ~ III; 3. Elective abdominal endoscopic surgery.
Exclusion criteria
Exclusion criteria: 1. Preoperative complicated with severe cardiopulmonary insufficiency, liver and kidney insufficiency, infectious diseases, immune system and blood system diseases; 2. Preoperative history of cognitive impairment, delirium, epilepsy, psychiatric disorders, anxiety, depression or family history; 3. Previous history of POCD, organic brain disease or cerebrovascular accident; 4. A history of heavy smoking, alcohol or drug dependence; 5. Hearing or visual impairment; 6. Recent use of anticholine drugs, anticonvulsants, anti-anxiety drugs, antidepressants, etc..
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time of Aldrete score =9 points after admission to PACU;The incidence of POGD;The incidence of POCD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Whether remedial analgesics (fentanyl) are used in PACU and the dosage used;Pain assessment;Serum IL-1, IL-6 and TNF- levels;Incidence of postoperative nausea and vomiting;opioid dosage; | — |
Countries
China
Contacts
Public ContactLi Li
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed