Cerebral palsy
Conditions
Interventions
Autologous cord blood group:Infusion of autologous cord blood mononuclear cells
Autologous umbilical plasma group:Infusion of autologous umbilical plasma
Placebo control group:Infusion of normal saline
Sponsors
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
0.3 Years to 10 Years
Inclusion criteria
Inclusion criteria: 1. Children who are diagnosed with cerebral palsy in our department from 3 months to 10 years old, regardless of gender; 2. Willing to follow all learning methods; 3. The umbilical cord blood group” requires that autologous cord blood be retained and willing to accept autologous cord blood infusion; 4. The "umbilical plasma group" requires willingness to inject autologous umbilical plasma; 5. The "control group" is the children who volunteered to participate in this study but refused autologous umbilical cord blood or umbilical plasma transfusion.
Exclusion criteria
Exclusion criteria: 1. There is a known genetic disease; 2. There are major organ diseases: such as severe microcephaly, refractory epilepsy, autism, progressive neurological disease, tachyarrhythmia, heart/lung/liver/kidney and other organ damage; 3. Have received cell therapy in the past, or need primary cell disease treatment; 4. There is a drug allergy related to this study; 5. The guardian's cooperation is not good, including uncoordinated rehabilitation and follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropsychological development;Immune Function;Head MR examination; | — |
Secondary
| Measure | Time frame |
|---|---|
| Organ function;Genetic examination; | — |
Countries
China
Contacts
Public ContactZhanwen He
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Outcome results
None listed