Type 2 diabetes
Conditions
Interventions
T2D group vs healthy control group:Nil
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. T2DM diagnostic criteria according to the 1999 World Health Organization criteria; 2. The recent poor glycemic control (HbA1C > 6.5%, or fasting blood glucose > 7.0mmol/L, or 2 hours postprandial glucose > 11.1mmol/L); 3. Aged between 18 and 75 years; 4. Signed an informed consent.
Exclusion criteria
Exclusion criteria: 1. Clinically significant major systemic disease, including severe hepatic and renal diseases, decompensated heart failure, myocardial infarction, malignant tumor, severe infection, etc; 2. Pregnant women; 3. Insulin-dependent diabetes patients; 4. Patients with the history of pancreatitis; 5. Patients with gastrointestinal diseases surgery or other abdominal surgery in the past 1 year; 6. Using drugs affect glucose metabolism in the previous 3 months, such as corticosteroids, thyroxine, etc; 7. Patients with acute complications of diabetes; 8. Patients with severe constipation, or acute and chronic diarrhea; 9. Yogurt ingestion within 1 week and antibiotics usage within 3 months before the first visit for stool sample collection; 10. Psychiatric patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| gut microbiota;metabonomics;pancreatic ß-cell function;insulin and C-peptide;FPG; | — |
Secondary
| Measure | Time frame |
|---|---|
| HbA1c;BMI;lipid levels;liver function;renal function;blood routine;total GLP-1;active GLP-1; | — |
Countries
China
Contacts
Public ContactLi Yuan
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed