Effect of remifentanil combined with dexmedetomidine on postoperative sleep quality in patients undergoing thoracoscopic lobectomy

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000034724

Enrollment

Unknown

Registered

2020-07-16

Start date

2020-08-01

Completion date

Unknown

Last updated

2020-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sleep disorders after thoracoscopic lobectomy

Interventions

Sufentanil + dexmedetomidine group:Application of Sufentanil combined with dexmedetomidine and tropisetron for postoperative patient-controlled analgesia

Remifentanil + dexmedetomidine group:Application of remifentanil combined with dexmedetomidine and tropisetron for postoperative patient-controlled analgesia

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) The patients who were scheduled for VATS lobectomy; (2) Aged 18-75 years; (3) American Association of anesthesiologists (ASA) grade I-II, BMI 18.5 kg / m2-28 kg / m2; (4) Patients agreed to receive PCIA.

Exclusion criteria

Exclusion criteria: (1) Pittsburgh sleep quality index score > 7; (2) patients with myasthenia gravis and respiratory depression; (3) patients with bronchial asthma; (4) patients receiving long-term anesthesia, analgesia, sedation or non steroidal anti-inflammatory drugs; (5) patients with sinus bradycardia (heart rate less than 50 beats) before operation; (6) long term use of anticonvulsant drugs, antidepressants or other psychotropic drugs; (7) taking monoamine oxidase inhibitors and allergic to the drugs in this study. (8) Severe heart, liver or kidney diseases; (9) participated in other clinical trials in the past 3 months; (10) had hearing and language communication barriers, and could not communicate effectively with doctors.

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative sleep disorders;	—

Secondary

Measure	Time frame
Ramsay score;The score of Athens Insomnia Scale;Resting and motor visual analogue (VAS) scores;Hospital Anxiety and Depression Scale score;;The times of effective compressions obtained from PCIA device within 48 hours after operation, and the demand for analgesic drugs was remedied;	—

Countries

China

Contacts

Public ContactCheng Wei

Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University

53974314@qq.com+86 18796205791

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026