Rectal cancer
Conditions
Interventions
experimental group:Transabdominal combined with posterior sacral approach for surgical treatment
control group:Non operative treatment
Sponsors
Peking University Shougang Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. The patients were older than 18 and less than 75 years old; 2. The patients whose lower edge of tumor is less than 5cm away from anal margin and can be expected to be resected, but the anus can not be preserved; 3. Pathological diagnosis of rectal cancer; Patients with T4 tumor confirmed by preoperative MRI staging; 4. Patients voluntarily accept this study, sign informed consent, and can cooperate with clinical follow-up.
Exclusion criteria
Exclusion criteria: 1. Rectal cancer with acute complications (complete intestinal obstruction, perforation and massive hemorrhage); 2. Pregnant or lactating female patients; 3. Patients with definite distant metastasis (including isolated liver and lung metastases), extensive intraperitoneal metastasis or cancerous ascites; 4. Patients with contraindication of operation; 5. Patients with cognitive impairment or mental illness; 6. The patients with urogenital dysfunction before operation; 7. Severe hepatic and renal insufficiency was defined as: alanine aminotransferase (ALT) or aspartate aminotransferase (AST) > 2.5 times of the upper limit of normal value, and serum creatinine > the upper limit of normal value; 8. Patients with allergic constitution or known allergy to allogeneic protein; 9. Other situations in which the doctor could not participate in the trial as judged by the doctor; 10. ASA grade IV or V; 11. Severe emphysema, interstitial pneumonia or ischemic heart disease can not tolerate surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| location and size of tumor;tumor grades and stages;CEA;MMR; | — |
Secondary
| Measure | Time frame |
|---|---|
| MSI;RAS;BRAF;PIK3CA;SMAD4;ß-catenin;PTEN; | — |
Countries
China
Contacts
Public ContactGu Jin
Peking University Shougang Hospital
Outcome results
None listed